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All issues Volume 39 (2026) Aquat. Living Resour., 39 (2026) 5 References
Issue
Aquat. Living Resour.
Volume 39, 2026
Special Issue - Interdisciplinary issues on Manila and European clams in their socio-ecosystems
Article Number 5
Number of page(s) 20
DOI https://doi.org/10.1051/alr/2025023
Published online 10 February 2026
  • Aebi H. Catalase in vitro, in: Methods in Enzymology, Academic Press, 1984, Vol. 105, pp. 121–126. [Google Scholar]
  • Agarwal R, Brunelli SM, Williams K Mitchell MD, Feldman HI, Umscheid CA. 2009. Gadolinium‐based contrast agents and nephrogenic systemic fibrosis: a systematic review and meta‐analysis. Nephrol Dial Transpl 24: 856–863. [Google Scholar]
  • Anderson MJ, Gorley RN, Clarke KR. PERMANOVA+ for PRIMER: Guide to Software and Statistical Methods, 2008. www.primer-e.com [Google Scholar]
  • Andrade M, Soares AMVM, Solé M, Pereira E, Freitas R. 2023. Gadolinium accumulation and its biochemical effects in Mytilus galloprovincialis under a scenario of global warming. Environ Sci Pollut Res 30: 116120–116133. [Google Scholar]
  • Andrade M, Soares AMVM, Solé M, Pereira E, Freitas R. 2022. Will climate changes enhance the impacts of e‐waste in aquatic systems? Chemosphere 288: 132264. [Google Scholar]
  • Andrade M, Soares AM, Solé M, Pereira E, Freitas R. 2021. Salinity influences on the response of Mytilus galloprovincialis to the rare‐earth element lanthanum. Sci Total Environ 794: 148512. [Google Scholar]
  • Arrigo F, De Marchi L, Meucci V, Piccione G, Soares AMVM, Faggio C, Freitas R. 2024. Mytilus galloprovincialis: a valuable bioindicator species for understanding the effects of diclofenac under warming conditions. Sci Total Environ 946: 173809. [Google Scholar]
  • Bates LS, Waldren RP, Teare ID. 1973. Rapid determination of free proline for water‐stress studies. Plant Soil 39: 205–207. [CrossRef] [Google Scholar]
  • Bau M, Dulski P. 1996. Anthropogenic origin of positive gadolinium anomalies in river waters. Earth Planet Sci Lett 143(1–4): 245–255. [Google Scholar]
  • Bau M, Knappe A, Dulski P. 2006. Anthropogenic gadolinium as a micropollutant in river waters in Pennsylvania and in Lake Erie, northeastern United States. Geochemistry 66: 143–152. [Google Scholar]
  • Beliaeff B, Burgeot T. 2002. Integrated biomarker response: a useful tool for ecological risk assessment. Environ Toxicol Chem 21: 1216–1322. [Google Scholar]
  • Boening DW. 1999. An evaluation of bivalves as biomonitors of heavy metals pollution in marine waters. Environ Monit Assess 55: 459‐470. [Google Scholar]
  • Briant N, Le Monier P, Bruzac S, Sireau T, Araújo DF, Grouhel A. 2021. Rare earth element in bivalves’ soft tissues of French metropolitan coasts: spatial and temporal distribution. Arch Environ Contam Toxicol 81: 600–611. [Google Scholar]
  • Brünjes R, Hofmann T. 2020. Anthropogenic gadolinium in freshwater and drinking water systems. Water Res 182: 115966. [Google Scholar]
  • Buer AL, Taylor D, Bergström P, Ritzenhofen L, Klemmstein A. 2020. Nitrogen and phosphorous content in blue mussels (Mytilus spp.) across the Baltic Sea. Front Mar Sci 7: 705. [Google Scholar]
  • Carregosa V, Velez C, Soares AMVM, Figueira E, Freitas R. 2014. Physiological and biochemical responses of three Veneridae clams exposed to salinity changes. Comp Biochem Physiol Part B: Biochem Mol Biol 177–178: 1–9. [Google Scholar]
  • Castro L, Farkas J, Jenssen BM, Piarulli S, Ciesielski TM. 2023. Biomonitoring of rare earth elements in Southern Norway: Distribution, fractionation, and accumulation patterns in the marine bivalves Mytilus spp. and Tapes spp.. Environmental Pollution 335: 122300. [Google Scholar]
  • Chen Z, Li X, Gao J, Liu Y, Zhang N, Guo Y, Wang Z, Dong Z. 2024. Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka. Chemosphere 357: 142103. [Google Scholar]
  • Čolović MB, Krstić DZ, Lazarević‐Pašti TD, Bondžić AM, Vasic VM. 2013. Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11: 315–335. [Google Scholar]
  • Coppola F, Bessa A, Henriques B, Russo T, Soares AMVM, Figueira E, Marques PAAP, Polese G, Di Cosmo A, Pereira E, Freitas R. 2020. Oxidative stress, metabolic and histopathological alterations in mussels exposed to remediated seawater by GO‐PEI after contamination with mercury. Comp Biochem Physiol Part A: Mol Integr Physiol 243: 110674. [Google Scholar]
  • Coughlan BM, Moroney GA, Pelt FNAMV, O'Brien NM, Davenport J, O'Halloran J. 2009. The effects of salinity on the Manila clam (Ruditapes philippinarum) using the neutral red retention assay with adapted physiological saline solutions. Mar Pollut Bull 58: 1680–1684. [Google Scholar]
  • Cunha M, Louro P, Silva M, Soares AMVM, Pereira E, Freitas R. 2022. Biochemical alterations caused by lanthanum and gadolinium in Mytilus galloprovincialis after exposure and recovery periods. Environ Pollut 307: 119387. [Google Scholar]
  • Dame RF. Ecology of Marine Bivalves: An Ecosystem Approach, 2nd edn, CRC Press, 2012, p. 283. [Google Scholar]
  • De Coen WM, Janssen CR. 1997. The use of biomarkers in Daphnia magna toxicity testing. IV. Cellular energy allocation: a new methodology to assess the energy budget of toxicant-stressed Daphnia populations J Aquat Ecosyst Stress Recover 6 (Kluwer Academic Publishers). [Google Scholar]
  • Defeo O, Elliott M. 2021. The ‘triple whammy’ of coasts under threat – why we should be worried! Mar Pollut Bull 163: 111832. [Google Scholar]
  • Dias JM, Lopes JF, Dekeyser I. 2000. Tidal propagation in Ria de Aveiro Lagoon, Portugal. Phys Chem Earth Part B: Hydrol Oceans Atmos 25: 369–374. [Google Scholar]
  • DuBois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. 1956. Colorimetric method for determination of sugars and related substances. Anal Chem 28: 350–356. [CrossRef] [Google Scholar]
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88–95. [CrossRef] [PubMed] [Google Scholar]
  • Fernández B, Campillo JA, Martínez‐Gómez C, Benedicto J. 2012. Assessment of the mechanisms of detoxification of chemical compounds and antioxidant enzymes in the digestive gland of mussels, Mytilus galloprovincialis, from Mediterranean coastal sites. Chemosphere 87: 1235–1245. [Google Scholar]
  • Figueiredo C, Grilo TF, Lopes C, Brito P, Caetano M, Raimundo J. 2022. Lanthanum and Gadolinium availability in aquatic mediums: New insights to ecotoxicology and environmental studies. J Trace Elem Med Biol 71: 126957. [Google Scholar]
  • Freitas R, Almeida Â, Calisto V, Velez C, Moreira A, Schneider RJ, Esteves VI, Wrona FJ, Figueira E, Soares AMVM. 2016. The impacts of pharmaceutical drugs under ocean acidification: New data on single and combined long‐term effects of carbamazepine on Scrobicularia plana. Sci Total Environ 541: 977–985. [Google Scholar]
  • Freitas R, Cardoso CED, Costa S, Morais T, Moleiro P, Lima AFD, Soares M, Figueiredo S, Águeda TL, Rocha P, Amador G, Soares AMVM, Pereira E. 2020. New insights on the impacts of e‐waste towards marine bivalves: the case of the rare earth element dysprosium. Environ Pollut 260: 113859. [Google Scholar]
  • Freitas R, Leite C, Pinto J, Costa M, Monteiro R, Henriques B, Di Martino F, Coppola F, Soares AMVM, Solé M, Pereira E. 2019. The influence of temperature and salinity on the impacts of lead in Mytilus galloprovincialis. Chemosphere 235: 403–412. [Google Scholar]
  • Freitas RO, Fraga M. Relatório Sanitário Para Zonas de Produção de Moluscos Bivalves: Ria de Aveiro, Instituto Português do Mar e da Atmosfera, 2020. [Google Scholar]
  • Gissi E, Manea E, Mazaris AD, Fraschetti S, Almpanidou V, Bevilacqua S, Coll M, Guarnieri G, Lloret‐Lloret E, Pascual M, Petza D, Rilov G, Schonwald M, Stelzenmüller V, Katsanevakis S. 2021. A review of the combined effects of climate change and other local human stressors on the marine environment. Sci Total Environ 755: 142564. [Google Scholar]
  • Gulani V, Calamante F, Shellock FG, Kanal E, Reeder SB. 2017. Gadolinium deposition in the brain: summary of evidence and recommendations. Lancet Neurol 16: 564–570. [Google Scholar]
  • Guo BJ, Yang ZL, Zhang LJ. 2018. Gadolinium deposition in brain: current scientific evidence and future perspectives. Front Mol Neurosci 11: 335. [Google Scholar]
  • Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S‐transferases. J Biol Chem 249: 7130–7139. [CrossRef] [PubMed] [Google Scholar]
  • Hanana H, Turcotte P, André C, Gagnon C, Gagné F. 2017. Comparative study of the effects of gadolinium chloride and gadolinium – based magnetic resonance imaging contrast agent on freshwater mussel, Dreissena polymorpha. Chemosphere 181: 197–207. [Google Scholar]
  • Henriques B, Coppola F, Monteiro R, Pinto J, Viana T, Pretti C, Soares A, Freitas R, Pereira E. 2019. Toxicological assessment of anthropogenic Gadolinium in seawater: biochemical effects in mussels Mytilus galloprovincialis. Sci Total Environ 664: 626–634. [Google Scholar]
  • Henriques IS, Alves A, Tacão M, Almeida A, Cunha Â, Correia A. 2006. Seasonal and spatial variability of free‐living bacterial community composition along an estuarine gradient (Ria de Aveiro, Portugal). Estuar Coast Shelf Sci 68(1–2): 139–148. [Google Scholar]
  • Hosokawa M, Satoh T. 2002. Measurement of carboxylesterase (CES) activities. Curr Protoc Toxicol 4: 4.7.1–4.7.14. [Google Scholar]
  • IPCC. 2019. Climate change and land: an IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems, in: P. R. Shukla, J. Skea, E. Calvo Buendía, V. Masson‐Delmotte, H.‐O. Pörtner, D. C. Roberts, P. Zhai, R. Slade, S. Connors, R. van Diemen, et al. (Eds.), Intergovernmental Panel on Climate Change, www.ipcc.ch/srccl/ [Google Scholar]
  • IPCC. 2023. Climate change 2023: synthesis report. Summary for policymakers, in: Core Writing Team, H. Lee, J. Romero (Eds.), Contribution of Working Groups I, II and III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change, IPCC, 10.59327/IPCC/AR6‐9789291691647.001 [Google Scholar]
  • Krasznai Z, Morisawa M, Krasznai ZT, Morisawa S, Inaba K, Bazsáné ZK, Rubovszky B, Bodnár B, Borsos A, Márián T. 2003. Gadolinium, a mechano‐sensitive channel blocker, inhibits osmosis‐initiated motility of sea‐ and freshwater fish sperm, but does not affect human or ascidian sperm motility. Cell Motility 55: 232–243. [Google Scholar]
  • Krishna S, Lemmen C, Örey S, Rehren J, Pane JD, Mathis M, Wirtz KW. 2025. Interactive effects of multiple stressors in coastal ecosystems. Front Mar Sci 11: 1481734. [Google Scholar]
  • Lachaux N, Otero‐Fariña A, Minguez L, Sohm B, Rétif J, Châtel A, Poirier L, Devin S, Pain‐Devin S, Gross EM, Giamberini L. 2023. Fate, subcellular distribution and biological effects of rare earth elements in a freshwater bivalve under complex exposure. Sci Total Environ 905: 167302. [Google Scholar]
  • Laczovics A, Csige I, Szabó S, Tóth A, Kálmán FK, Tóth I, Braun M. 2023. Relationship between gadolinium‐based MRI contrast agent consumption and anthropogenic gadolinium in the influent of a wastewater treatment plant. Sci Total Environ 877: 162844. [Google Scholar]
  • Leite C, Russo T, Polese G, Soares AMVM, Pretti C, Pereira E, Freitas R. 2024. Effects of the interaction of salinity and rare earth elements on the health of Mytilus galloprovincialis: the case of Praseodymium and Europium. J Xenobiotics 14: 2015–2038. [Google Scholar]
  • Li Y, Li Y, Lai Q, Yao Z, Zhou K, Niu D. 2024. Proline metabolism and its osmotic regulatory role in enhancing hypersalinity tolerance of the razor clam (Sinonovacula constricta). Aquaculture 589. https://doi.org/10.1016/j.aquaculture.2024.741019. [Google Scholar]
  • Lopes JF, Lopes CL, Dias JM. 2021. Extreme meteorological events in a coastal lagoon ecosystem: the ria de Aveiro lagoon (Portugal) case study. J Mar Sci Eng 9: 727. [Google Scholar]
  • Magnani L, Gaydou EM, Hubaud JC. 2000. Spectrophotometric measurement of antioxidant properties of flavones and flavonols against superoxide anion. Anal Chim Acta 411(1–2): 209–216. [Google Scholar]
  • Mennillo E, Casu V, Tardelli F, De Marchi L, Freitas R, Pretti C. 2017. Suitability of cholinesterase of polychaete Diopatra neapolitana as biomarker of exposure to pesticides: In vitro characterization. Comp Biochem Physiol Part C: Toxicol Pharmacol 191: 152–159. [Google Scholar]
  • Mesquita CS, Oliveira R, Bento F, Geraldo D, Rodrigues JV, Marcos JC. 2014. Simplified 2,4‐dinitrophenylhydrazine spectrophotometric assay for quantification of carbonyls in oxidized proteins. Anal Biochem 458: 69–71. [Google Scholar]
  • Moreira I, Pereira E, Soares AMVM, Freitas R. 2025. Gadolinium: a review on concentrations and impacts in marine and coastal systems. Environ Pollut 381: 126453. [Google Scholar]
  • Mossotto C, Anselmi S, Trevisan S, Provenza F, Maganza A, Gabetti A, Esposito G, Elia AC, Prearo M, Renzi M, Pastorino P. 2025. Assessing the toxicity of gadolinium in freshwater and marine ecosystems: effects across trophic levels. Environ Toxicol Pharmacol 115: 104673. [Google Scholar]
  • Munari M, Matozzo V, Marin MG. 2011. Combined effects of temperature and salinity on functional responses of haemocytes and survival in air of the clam Ruditapes philippinarum. Fish Shellfish Immunol 30(4–5): 1024–1030. [Google Scholar]
  • Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351–358. [CrossRef] [PubMed] [Google Scholar]
  • Packard T, King F. 1975. Respiration and the activity of the respiratory electron transport system in marine zooplankton1. Limnol Oceanogr 20: 849–854. [Google Scholar]
  • Patel N, Khan MDZA, Shahane S, Rai D, Chauhan D, Kant C, Chaudhary VK. 2020. Emerging pollutants in aquatic environment: source, effect, and challenges in biomonitoring and bioremediation‐ a review. Pollution 6. https://doi.org/10.22059/poll.2019.285116.646. [Google Scholar]
  • Perrat E, Parant M, Py J‐S, Rosin C, Cossu‐Leguille C. 2017. Bioaccumulation of gadolinium in freshwater bivalves. Environ Sci Pollut Res 24: 12405–12415. [Google Scholar]
  • Queirós V, Leite C, Azeiteiro UM, Belloso MC, Soares AMVM, Santos JL, Alonso E, Barata C, Freitas R. 2024. Salinity influence on Mytilus galloprovincialis exposed to antineoplastic agents: a transcriptomic, biochemical, and histopathological approach. Environ Pollut 363: 125135. [Google Scholar]
  • Rainbow PS. 2002. Trace metal concentrations in aquatic invertebrates: why and so what? Environ Pollut 120: 497–507. [Google Scholar]
  • Regoli F, Giuliani ME. 2014. Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms. Mar Environ Res 93: 106–117. [Google Scholar]
  • Rétif J, Zalouk‐Vergnoux A, Briant N, François Y, Poirier L. 2024a. Trophic dilution of rare earth elements along the food chain of the Seine estuary (France). Mar Pollut Bull 206: 116671. [Google Scholar]
  • Rétif J, Zalouk‐Vergnoux A, Kamari A, Briant N, Poirier L. 2024b. Trophic transfer of rare earth elements in the food web of the Loire estuary (France). Sci Total Environ 914: 169652. [Google Scholar]
  • Revel M, Van Drimmelen CK, Weltje L, Hursthouse A, Heise S. 2025. Effects of rare earth elements in the aquatic environment: implications for ecotoxicological testing. Crit Rev Environ Sci Technol 55: 334–375. [Google Scholar]
  • Rivera‐Ingraham GA, Lignot J‐H. 2017. Osmoregulation, bioenergetics and oxidative stress in coastal marine invertebrates: raising the questions for future research. J Exp Biol 220: 1749–1760. [Google Scholar]
  • Robinson HW, Hogden CG. 1940. The biuret reaction in the determination of serum proteins. J Biol Chem 135: 727–731. [Google Scholar]
  • Rogowska J, Olkowska E, Ratajczyk W, Wolska L. 2018. Gadolinium as a new emerging contaminant of aquatic environments. Environ Toxicol Chem 37: 1523–1534. [Google Scholar]
  • Schmidt K, Bau M, Merschel G, Tepe N. 2019. Anthropogenic gadolinium in tap water and in tap water-based beverages from fast-food franchises in six major cities in Germany. Sci Total Environ 687: 1401–1408. [Google Scholar]
  • Sanchez W, Burgeot T, Porcher J‐M. 2013. A novel “Integrated Biomarker Response” calculation based on reference deviation concept. Environ Sci Pollut Res 20: 2721–2725. [Google Scholar]
  • Sauvé S, Desrosiers M. 2014. A review of what is an emerging contaminant. Chem Central J 8: 15. [Google Scholar]
  • Santos D, Leite C, Pinto J, Soares AM, Pereira E, Freitas R. 2023. How will different scenarios of rising seawater temperature alter the response of marine species to lithium?. Sci Total Environ 856: 158728. [Google Scholar]
  • Santos L, Cunha Â, Silva H, Caçador I, Dias JM, Almeida A. 2007. Influence of salt marsh on bacterial activity in two estuaries with different hydrodynamic characteristics (Ria de Aveiro and Tagus Estuary): influence of salt marsh on bacterial activity in estuaries. FEMS Microbiol Ecol 60: 429–441. [Google Scholar]
  • Secco S, Cunha M, Libralato G, Trifuoggi M, Giarra A, Soares AMVM, Freitas R, Scalici M. 2024. Evaluating the impact of gadolinium contamination on the marine bivalve Donax trunculus: implications for environmental health. Environ Toxicol Pharmacol 112: 104580. [Google Scholar]
  • Solé M, Rivera‐Ingraham G, Freitas R. 2018. The use of carboxylesterases as biomarkers of pesticide exposure in bivalves: a methodological approach. Comp Biochem Physiol Part C: Toxicol Pharmacol 212: 18–24. [Google Scholar]
  • Spampinato M, Siciliano A, Travaglione A, Chianese T, Mileo A, Libralato G, Guida M, Trifuoggi M, De Gregorio V, Rosati L. 2024. Unravelling the ecotoxicological impacts of gadolinium (Gd) on Mytilus galloprovincialis embryos and sperm in seawater: a preliminary study. Heliyon 10: e31087. [Google Scholar]
  • Stączek S, Kunat‐Budzyńska M, Cytryńska M, Zdybicka‐Barabas A. 2024. Proline‐rich antimicrobial peptides from invertebrates. Molecules 29: 5864. [Google Scholar]
  • Sturla Lompré J, Cunha M, Pinto J, Soares AMVM, Pereira E, Freitas R. 2025. Cellular responses of Ruditapes philippinarum clams to global changes: assessing the risks of rising temperatures and E‐waste. Estuar Coast Shelf Sci 319: 109262. [Google Scholar]
  • Trapasso G, Chiesa S, Freitas R, Pereira E. 2021. What do we know about the ecotoxicological implications of the rare earth element gadolinium in aquatic ecosystems? Sci Total Environ 781: 146273. [Google Scholar]
  • Telgmann L, Wehe CA, Birka M, Kuünnemeyer J, Nowak S, Sperling M, Karst U. 2012. Speciation and isotope dilution analysis of gadolinium-based contrast agents in wastewater. Environ Sci Technol 46: 11929–11936. [Google Scholar]
  • van der Molen AJ, Quattrocchi CC, Mallio CA, Dekkers IA, European Society of Magnetic Resonance in Medicine, Biology Gadolinium Research, Educational Committee (ESMRMB‐GREC). 2024. Ten years of gadolinium retention and deposition: ESMRMB‐GREC looks backward and forward. Eur Radiol 34: 600–611. [Google Scholar]
  • Vaz L, Frankenbach S, Serôdio J, Dias JM. 2019. New insights about the primary production dependence on abiotic factors: Ria de Aveiro case study. Ecol Indic 106: 105555. [Google Scholar]
  • Velez C, Figueira E, Soares AMVM, Freitas R. 2017. Effects of seawater temperature increase on economically relevant native and introduced clam species. Mar Environ Res 123: 62–70. [Google Scholar]
  • Willett CS, Burton RS. 2002. Proline biosynthesis genes and their regulation under salinity stress in the euryhaline copepod Tigriopus californicus. Comp Biochem Physiol Part B: Biochem Mol Biol 132: 739–750. [Google Scholar]
  • Yang F, Zhao L, Yan X, Wang Y. 2013. Bioaccumulation of trace elements in Ruditapes philippinarum from China: public health risk assessment implications. Int J Environ Res Public Health 10: 1392–1405. [Google Scholar]
  • Zhou C, Xu L, Song H, Feng J, Hu Z, Yang M‐J, Shi P, Li Y‐R, Guo Y‐J, Li H‐Z, Zhang T. 2023. Examination of the regulation of energy metabolism, antioxidant response, and ammonia detoxification in hard clam, Mercenaria mercenaria, under hypersalinity stress. Aquaculture 563: 738916. [Google Scholar]
  • Zitoun R, Marcinek S, Hatje V, Sander SG, Völker C, Sarin M, Omanović D. 2024. Climate change driven effects on transport, fate and biogeochemistry of trace element contaminants in coastal marine ecosystems. Commun Earth Environ 5: 560. [Google Scholar]
  • Zuykov M, Pelletier E, Harper DAT. 2013. Bivalve mollusks in metal pollution studies: From bioaccumulation to biomonitoring. Chemosphere 93: 201–208. [Google Scholar]

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